分享到:

合成温敏型PLGA-PEG-PLGA嵌段共聚物

本报河北讯 记者白毅报道 药用辅料对于制剂成型,以及工艺过程顺利、稳定进行提供了重要保证,一直是药剂学  (本文共1页) 阅读全文>>

《Asian Journal of Pharmaceutical Sciences》2018年01期
Asian Journal of Pharmaceutical Sciences

Preparation of poly(lactide-co-glycolide)microspheres and evaluation of pharmacokinetics and tissue distribution of BDMC-PLGA-MS in rats

The aim of the present study was to develop a novel long-acting Poly(lactic-co-glycolic acid)(PLGA)-based microspheres formulation of Bisdemethoxycurcum(BDMC) by emulsionsolvent evaporation method. Meanwhile, the effects of the volume ratio of the dispersed phase and continuous phase, the concentration of PLGA and PVA, the theoretical drug loading and stirring speed were investigated. The mean diameter of the microsp...  (本文共9页) 阅读全文>>

《Transactions of Tianjin University》2019年02期
Transactions of Tianjin University

Mechanical Properties and Degradability of Electrospun PCL/PLGA Blended Scaffolds as Vascular Grafts

In our study, the mechanical properties and degradability of vascular grafts made from poly(ε-caprolactone)(PCL) and poly(lactic-co-glycolic acid)(PLGA) at different ratios were investigated. The results showed that the electrospun PCL/PLGA grafts possess good mechanical properties and biodegradability. The tensile and burst s...  (本文共9页) 阅读全文>>

《植物研究》2019年04期
植物研究

包载紫杉醇PLGA纳米粒的制备工艺优化及表征

以生物可降解材料乳酸—羟基乙酸共聚物[poly(lactic-co-glycolic acid),PLGA]为载体材料,采用乳化—溶剂挥发法制备包载紫杉醇(PTX)的PLGA微球(PTX-PLGA NPs)。采用正交实验设计,考察乳化剂质量浓度、PLGA与紫杉醇质量比、油相用量、剪切速度4个因素对粒径和载药率的影响,优化纳米粒最佳制备工艺。研究结...  (本文共7页) 阅读全文>>

《长沙医学院学报》2019年01期
长沙医学院学报

Spermidine mediated PLGA nanoparticles containing fluorofenidone for treatment of idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis(IPF) is a progressive, fatal lung disease with poor survival. The advances made in deciphering IPF have led to the approval of different anti-fibrotic molecules, such as pirfenidone and nintedanib. An increasing number of studies with particles(liposomes, nanoparticles, microspheres, nanopolymersomes and nanoliposomes) modified with different functional groups have demonstrated improveme...  (本文共21页) 阅读全文>>

《Chinese Journal of Biomedical Engineering》2017年03期
Chinese Journal of Biomedical Engineering

Modification of PLGA Scaffolds for Vascular Tissue Engineering

We report this modification of poly(lactic-coglycolic acid)(PLGA)scaffolds, both to impart hemocompatibility to prevent platelet adhesion and aggregation before the endothelial confluence is fully achieved, and to support EC growth to accelerate endothelialization. The modification was achieved by covalent immobilization of sulfated silk fibroin on PLGA scaffolds using gamma irradiation. The systematic in vitro hemoc...  (本文共4页) 阅读全文>>