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Richter's综合征:IGVH基因克隆重排及突变分析

Richter's综合征(Richter's syndrome)是指慢性B淋巴细胞性白血病(B cell chronic lymphocytic leukemia,B-CLL)患者进一步发展为高度恶性的大细胞淋巴瘤。主要为弥漫性大B细胞淋巴瘤(Diffuse large B-cell lymphoma,DLBCL)即经典型Richter's综合征和霍奇金淋巴瘤(Hodgkin lymphoma,HL)即HL亚型Richter's综合征。Richter's综合征临床预后极差,中位生存时间不超过一年。未突变型免疫球蛋白重链可变区(Immunoglobulin heavy chainvariable region,IGVH)基因是B-CLL患者临床恶性进展的指标。有报道发现携带突变型和未突变型IGVH基因的B-CLL均可向Richter's综合征转化。转化的DLBCL或HL可以是与相应B-CLL克隆相关的,也有克隆不相关的病例。但Ri  (本文共108页) 本文目录 | 阅读全文>>

《Earthquake Research in China》2003年04期
Earthquake Research in China

Calculation of Calibration Functions and Explosive Aftershock Magnitudes in the Near Field

The current calibration function used in calculating the magnitude of natural earthquakes within 5km is a constant; a fact that causes several serious difficulties for the calculation of the magnitude of small and shallow-focus earthquakes. According to the attenuation law of explosions and the propagation theory of elastic...  (本文共10页) 阅读全文>>

《Chinese Journal of Lasers》2001年03期
Chinese Journal of Lasers

Fiber Ring Laser In-cavity Phase Modulation

In this paper, experimental results of the in\|cavity phase modulation induced by dithering PZT is reported. Th...  (本文共6页) 阅读全文>>

《1997 Annual Report of Institute of Modern Physics,the Chinese Academy of Sciences & National Laboratory of Heavy Ion Accelerator,Lanzhou》1997年00期
1997 Annual Report of Institute of Modern Physics,the Chinese Academy of Sciences & National Laboratory of Heavy Ion Accelerator,Lanzhou

Measurement of Excitation Function in Dissipative Collision~(27)Al+~(27)Al

Measurementsofexcitationfunctionsofproductsindissipat...  (本文共2页) 阅读全文>>

《四川医学》1988年01期
四川医学

婴儿Richter氏疝一例

文锦等(成都市儿童医阮)报道:患儿,男,60天,体重3...  (本文共1页) 阅读全文>>

《临床与病理杂志》2017年11期
临床与病理杂志

Richter综合征1例并文献复习

慢性淋巴细胞白血病(chronic lymphocytic leukemia,CLL)发生Richter转化的机制尚未完全明确,治疗上通常参照侵袭性非霍奇金淋巴瘤或急性淋巴细胞白血病的...  (本文共3页) 阅读全文>>