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二代PAMAM树型高分子的荧光现象及其荧光标记应用

首次发现不含荧光团的二代poly(amido a-mine)(PAMAM)树型高分子的荧光现象,研究结果表明在无荧光基团的PAMAM树型高分子中,胺类官能团  (本文共3页) 阅读全文>>

《Journal of Rare Earths》2006年01期
Journal of Rare Earths

Molecular Dynamics and Preparation of HO-PAMAM-2.5G Protected Lanthanum Cluster

HO-PAMAM-2.5 G-protected lanthanum cluster was studied by Virtual Molecule(VM) software. Molecular dynamics (MD) simulation of the nanocomposite system was performed from the view-points of molecular structure and energy′s fluctuation in NVT system. The motivation of this work was to understand the stability and mechanism of the nanocomposite in different proportion. The molecular dynamics simulation results reveal t...  (本文共1页) 阅读全文>>

《中国原子能科学研究院年报》2017年00期
中国原子能科学研究院年报

小角散射研究PAMAM树形大分子及其复合物

利用小角中子和X射线散射方法,研究温度对溶液中第5代PAMAM树形大分子分子间结构的影响。随着温度的升高,结构因子散射峰逐渐宽化。这是由于分子间库仑相互作用引起的分子间类液态有序排列,受...  (本文共2页) 阅读全文>>

《Chinese Chemical Letters》2016年09期
Chinese Chemical Letters

Adhesive peptides conjugated PAMAM dendrimer as a coating polymeric material enhancing cell responses

This present work aims to functionalize poly(amidoamine)(PAMAM) dendrimers with various reported adhesive peptides, including Arg-Gly-Asp(RGD), Tyr-Ile-Gly-Ser-Arg(YIGSR), and Ile-Lys-Val-Ala-Val(IKVAV) for enhancing cell responses. The RGD, YIGSR, or IKVAV functionalized PAMAM coated subs...  (本文共6页) 阅读全文>>

《中国药理学与毒理学杂志》2016年10期
中国药理学与毒理学杂志

Neuroprotective effect of Angiopep-2 peptide modified scutellarin-loaded PEGylated PAMAM dendrimer nanoparticles on ischemic stroke by modulating the Toll-like receptors-dependent MyD88/IKK/NF-κB signaling pathway

OBJECTIVE The greatest challenge in chemotherapy of ischemic stroke is the construction a suitable delivery system to overcome the poor physicochemical properties of drug and its low permeability across the blood brain barrier(BBB).METHODS In the present study,dendrimer,polyamidoamine(PAMAM),was synthesized as the nano-drug carriers.Angiopep-2,which has been proved excellent ability to cross the BBB,was exploited as ...  (本文共2页) 阅读全文>>

《数理医药学杂志》2012年03期
数理医药学杂志

PAMAM作为抗肿瘤药物载体研究进展

树枝状大分子是一类新型的高分子材料,具有高度枝化、结构可控、单分散等特点,其中聚酰胺-胺型大分子(Poly-amid...  (本文共4页) 阅读全文>>