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Schwann细胞与筋膜共同培养的实验研究

目的探讨Schwann细胞与筋膜共同培养的方法 ,为神经缺损修复提供实验基础。方法将Schwann细胞与筋膜共同培养 ,免疫组织化学双染、相差显微镜连续观察及间接免疫荧光染色显示Schwann细胞胶质特异性标记蛋白S 10 0表达和BrdU掺入。结果相差显微镜下可见筋膜周围有  (本文共3页) 阅读全文>>

《Chinese Journal of Traumatology》2004年04期
Chinese Journal of Traumatology

Schwann cell apoptosis in Wallerian-degenerated sciatic nerve of the rat

Objective: To investigate systematically Schwann cell apoptosis in Wallerian-degenerated sciatic nerve of the rat,and evaluate its time-related feature. Methods: Ninety-five SD rats were divided randomly into one no rmal group (8 rats) and 11 experimental groups (66 rats,6 in each). Both hind l egs of each rat in experimental groups were randomly divided into test leg (scia tic nerve transected) and control one (nerv...  (本文共9页) 阅读全文>>

《解剖科学进展》2004年03期
解剖科学进展

Schwann细胞与其培养纯化

Schwann细胞是周围神经系统的主要功能细胞 ,兼有迁移、粘着、产生细胞外基质、形成髓鞘 ,参与周围神经修...  (本文共5页) 阅读全文>>

《Neural Regeneration Research》2020年01期
Neural Regeneration Research

Claudin-15 overexpression inhibits proliferation and promotes apoptosis of Schwann cells in vitro

Our previous experiments have discovered that Claudin-15 was up-regulated in Schwann cells of the distal nerve stumps of rat models of sciatic nerve injury. However, how Claudin-15 affects Schwann cell function is still unknown. This study aimed to identify the effects of Claudin-15 on proliferation and apoptosis of Schwann cells cultured in vitro and explore the underlying mechanisms. Primary Schwann cells were obta...  (本文共9页) 阅读全文>>

《Neural Regeneration Research》2019年03期
Neural Regeneration Research

3-N-Butylphthalide mitigates high glucose-induced injury to Schwann cells:association with nitrosation and apoptosis

A high glucose state readily causes peripheral axon atrophy, demyelination, loss of nerve fiber function, and delayed regeneration. However, few studies have examined whether nitration is also critical for diabetic peripheral neuropathy. Therefore, this study investigated the effects of high glucose on proliferation, apoptosis, and 3-nitrotyrosine levels of Schwann cells treated with butylphthalide. In addition, we e...  (本文共6页) 阅读全文>>

《Neural Regeneration Research》2019年06期
Neural Regeneration Research

Comparative study of microarray and experimental data on Schwann cells in peripheral nerve degeneration and regeneration: big data analysis

A Schwann cell has regenerative capabilities and is an important cell in the peripheral nervous system.This microarray study is part of a bioinformatics study that focuses mainly on Schwann cells. Microarray data provide information on differences between microarray-based and experiment-based gene expression analyses. According to microarray data, several genes exhibit increased expression(fold change) but they are w...  (本文共6页) 阅读全文>>