分享到:

急性缺血性脑卒中患者外周血sE-selectin、sL-selectin、CD54、CD62p、CD42b表达研究

目的:研究急性缺血性脑卒中(acute ischemic stroke,AIS)患者外周血中性粒细胞(polymorphonuclear,PMN)和单核细胞(mononuclear leukocyte,MNL)表面细胞间粘附分子-1(intercellular adhesion molecule,ICAM-1,CD54)、C-反应蛋白(C-reactive protein, CRP)、可溶性E-选择素(soluble E-selectin,sE-selectin)、可溶性L-选择素(soluble L-selectin,sL-selectin)及血小板(platelet,PLT)表面P-选择素(P-selectin ,CD62p)、CD42b表达的变化与意义;探讨患者外周血炎性反应相关指标与活化血小板指标之间的相关性;以及上述各指标与脑梗死体积间的关系。方法:采用流式细胞术,以单克隆抗体标记并定量测定71例AIS患者在发病72h  (本文共52页) 本文目录 | 阅读全文>>

《The Journal of Biomedical Research》2016年01期
The Journal of Biomedical Research

Myocardin-related transcription factor A cooperates with brahmarelated gene 1 to activate P-selectin transcription

Expression of P-selectin in injured or activated endothelia cells serves as a permissive step towards leukocyte recruitment and perpetuation of inflammation in the pathogenesis of atherosclerosis.P-selectin can be induced by pro-inflammatory stimuli via the transcription factor NF-κB,but the epigenetic mechanisms remain incompletely understood.Previously we reported that myocardin-related transcription factor A(MRTF-...  (本文共7页) 阅读全文>>

《World Journal of Gastroenterology》2008年44期
World Journal of Gastroenterology

Failure of P-selectin blockade alone to protect the liver from ischemia-reperfusion injury in the isolated blood-perfused rat liver

AIM:To determine if blockade of P-selectin in the isolated blood-perfused cold ex vivo rat liver model protects the liver from ischemia-reperfusion injury. METHODS:The effect of P-selectin blockade was assessed by employing an isolated blood-perfused cold ex vivo rat liver with or without P-selectin antibody treatment before and after 6 h of cold storage in University of Wisconsin solution. RESULTS:In our isolated bl...  (本文共9页) 阅读全文>>

《江苏医药》2006年03期
江苏医药

选择素在特发性血小板减少性紫癜中的表达

目的研究选择素的表达在特发性血小板减少性紫癜(ITP)发生中的作用。方法激素治疗ITP23例中,13例疗效不良者为A组,10例疗效良好者为B组;另8例肝硬化脾亢者为C组,15名健康献血者为D组。抽全血用ELISA法检测可溶性E-选择素(E-selectin)、可溶性L-选择素(sL-selectin)、可溶性P-选择素(sP-selectin);通过流式细胞仪检测P-选择素(P-selectin)及L-选择素(L-selectin)。结果血小板计数,A组为34.2×109/L,B组35.6×109/L,C组56.3×109/L,D组1...  (本文共2页) 阅读全文>>

《China Medical Abstracts(Internal Medicine)》2006年04期
China Medical Abstracts(Internal Medicine)

The association of single nucleotide P-selectin gene polymorphism with IgA nephropathy

Objective IgA nephropathy is one of the most com- mon form of primary glomerulonephritis throughout the world and a main renal disease which causes renal failure. P-selecti...  (本文共1页) 阅读全文>>

《World Journal of Gastroenterology》2006年08期
World Journal of Gastroenterology

Higher platelet P-selectin in male patients with inflammatory bowel disease compared to healthy males

AIM:To observe if the total amount of platelet P-selectin(tP-selectin)in patients with inflammatory bowel disease(IBD)was related to disease entity or activity,5-ami-nosalicylic acid(5-ASA)medication or gender.METHODS:tP-selectin was measured by immunoassayin seventeen IBD patients and twelve healthy controls.RESULTS:Compared to controls,ther...  (本文共3页) 阅读全文>>