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合成温敏型PLGA-PEG-PLGA嵌段共聚物

本报河北讯 记者白毅报道 药用辅料对于制剂成型,以及工艺过程顺利、稳定进行提供了重要保证,一直是药剂学  (本文共1页) 阅读全文>>

《Chinese Journal of Chemical Engineering》2021年01期
Chinese Journal of Chemical Engineering

Highly interconnected macroporous MBG/PLGA scaffolds with enhanced mechanical and biological properties via green foaming strategy

In this study,mesoporous bioactive glass particles(MBGs) are incorporated into poly(lactic-co-glycolic acid)(PLGA) to fabricate highly interconnected macroporous composite scaffolds with enhanced mechanical and biological properties via a developed supercritical carbon dioxide(scCO_2) foaming method Scaffolds show favorable highly interconnected and macroporous structure through a high foaming pressure and long venti...  (本文共11页) 阅读全文>>

《Journal of Pharmaceutical Analysis》2021年01期
Journal of Pharmaceutical Analysis

Evaluation of apoptotic effects of mPEG-b-PLGA coated iron oxide nanoparticles as a eupatorin carrier on DU-145 and LNCaP human prostate cancer cell lines

Many studies have so far confirmed the efficiency of phytochemicals in the treatment of prostate cancer.Eupatorin, a flavonoid with a wide range of phytomedical activities, suppresses proliferation of and induces apoptosis of multiple cancer cell lines. However, low solubility, poor bioavailability, and rapid degradation limit its efficacy. The aim of our study was to evaluate whether the use of m PEG-b-poly(lactic-c...  (本文共14页) 阅读全文>>

《Acta Pharmaceutica Sinica B》2021年04期
Acta Pharmaceutica Sinica B

Uptake and traffcking of different sized PLGA nanoparticles by dendritic cells in imiquimod-induced psoriasis-like mice model

Psoriasis is an autoimmune infammatory disease, where dendritic cells(DCs) play an important role in its pathogenesis. In our previous work, we have demonstrated that topical delivery of curcumin-loaded poly(lactic-co-glycolic acid)(PLGA) nanoparticles(NPs) could treat Imiquimod(IMQ)-induced psoriasis-like mice. The objective of this study is to further elucidate biofate of PLGA NPs after intradermal delivery includi...  (本文共9页) 阅读全文>>

《亚太传统医药》2020年03期
亚太传统医药

姜黄素PLGA纳米颗粒的制备及表征

目的:筛选姜黄素PLGA纳米粒(Cur-PLGA-NPs)制备的最优处方,并对制备的纳米粒进行表征。方法:以聚乳酸羟基乙酸共聚物(PLGA)为载体材料,采用乳化溶剂挥发法制备Cur-PLGA-NPs,通过单因素试验,以粒径、包封率和载药量为指标,筛选了Cur-PLGA-NPs...  (本文共4页) 阅读全文>>

《Asian Journal of Pharmaceutical Sciences》2020年03期
Asian Journal of Pharmaceutical Sciences

Development of composite PLGA microspheres containing exenatide-encapsulated lecithin nanoparticles for sustained drug release

This study aimed to prepare poly(D, L-lactic-co-glycolic acid) microspheres(PLGA-Ms)by a modified solid-in-oil-in-water(S/O/W) multi-emulsion technique in order to achieve sustained release with reduced initial burst and maintain efficient drug concentration for a prolonged period of time. Composite PLGA microspheres containing exenatideencapsulated lecithin nanoparticles(Ex-NPs-PLGA-Ms) were obtained by initial fabr...  (本文共9页) 阅读全文>>