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合成温敏型PLGA-PEG-PLGA嵌段共聚物

本报河北讯 记者白毅报道 药用辅料对于制剂成型,以及工艺过程顺利、稳定进行提供了重要保证,一直是药剂学  (本文共1页) 阅读全文>>

《中国生物医学工程学报》2022年01期
中国生物医学工程学报

磁性多孔PLGA微球制备及其功能化研究

磁性微球是一种具有磁响应性的复合功能材料。以共沉淀法制备的Fe_3O_4纳米颗粒为铁磁性原料,通过溶剂挥发法制备Fe_3O_4/PLGA磁性高分子复合微球。光镜及扫描电镜观察微球形貌并测定元素组成,确定合成了粒径约为15μm的磁性高分子复合微球...  (本文共5页) 阅读全文>>

《西北药学杂志》2022年01期
西北药学杂志

负载替米沙坦PLGA纳米粒的制备与膜渗透性评价

目的 制备和优化替米沙坦聚乳酸-羟基乙酸共聚物(poly lactic-co-glycotic acid, PLGA)纳米粒(TMS-loaded PLGA NPs),并通过Caco-2细胞单层模型评价其体外渗透性。方法 以PLGA作为载体材料,采用溶剂蒸发法制备TMS-loaded PLGA NPs,以替米沙坦质量浓度(x_1)、PLGA质量浓度(x_2)和Poloxamer 188质量浓度(x_3)作为考察因素,以纳米粒的包封率(y_1)和粒径大小(y_2)作为评价指标,通过3因素3水平析因设计优化TMS-loaded PLGA NPs处方;通过透射电镜观察...  (本文共6页) 阅读全文>>

《Chinese Journal of Chemical Engineering》2021年01期
Chinese Journal of Chemical Engineering

Highly interconnected macroporous MBG/PLGA scaffolds with enhanced mechanical and biological properties via green foaming strategy

In this study,mesoporous bioactive glass particles(MBGs) are incorporated into poly(lactic-co-glycolic acid)(PLGA) to fabricate highly interconnected macroporous composite scaffolds with enhanced mechanical and biological properties via a developed supercritical carbon dioxide(scCO_2) foaming method Scaffolds show favorable highly interconnected and macroporous structure through a high foaming pressure and long venti...  (本文共11页) 阅读全文>>

《Journal of Pharmaceutical Analysis》2021年01期
Journal of Pharmaceutical Analysis

Evaluation of apoptotic effects of mPEG-b-PLGA coated iron oxide nanoparticles as a eupatorin carrier on DU-145 and LNCaP human prostate cancer cell lines

Many studies have so far confirmed the efficiency of phytochemicals in the treatment of prostate cancer.Eupatorin, a flavonoid with a wide range of phytomedical activities, suppresses proliferation of and induces apoptosis of multiple cancer cell lines. However, low solubility, poor bioavailability, and rapid degradation limit its efficacy. The aim of our study was to evaluate whether the use of m PEG-b-poly(lactic-c...  (本文共14页) 阅读全文>>

《Acta Pharmaceutica Sinica B》2021年04期
Acta Pharmaceutica Sinica B

Uptake and traffcking of different sized PLGA nanoparticles by dendritic cells in imiquimod-induced psoriasis-like mice model

Psoriasis is an autoimmune infammatory disease, where dendritic cells(DCs) play an important role in its pathogenesis. In our previous work, we have demonstrated that topical delivery of curcumin-loaded poly(lactic-co-glycolic acid)(PLGA) nanoparticles(NPs) could treat Imiquimod(IMQ)-induced psoriasis-like mice. The objective of this study is to further elucidate biofate of PLGA NPs after intradermal delivery includi...  (本文共9页) 阅读全文>>