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Ron receptor-dependent gene regulation of Kupffer cells during endotoxemia

BACKGROUND: Ron receptor tyrosine kinase signaling in macrophages, including Kupffer cells and alveolar macrophages,suppresses endotoxin-induced proinflammatory cytokine/chemokine production. Further, we have also identified genes from Ron replete and Ron deplete livers that were differentially expressed during the progression of liver inflammation associated with acute liver failure in mice by microarray analyses.Wh  (本文共12页) 阅读全文>>

《中国普外基础与临床杂志》2020年10期
中国普外基础与临床杂志

Kupffer细胞在肝移植缺血再灌注损伤中的作用

目的分析Kupffer细胞(KCs)与肝移植缺血再灌注损伤(IRI)的关系。方法收集近年KCs在肝移植IRI中研究的相关文献并进行综述。结果近年研究表明,先天性免疫与适应性免疫皆与肝脏IRI的发生、发展以及KCs...  (本文共4页) 阅读全文>>

《免疫学杂志》2019年03期
免疫学杂志

大鼠肝纤维化进程中原代Kupffer细胞吞噬能力及表型变化特征研究

目的考察肝纤维化不同阶段原代Kupffer细胞吞噬能力及M1型和M2型Kupffer细胞占比的变化趋势。方法 SD大鼠腹腔注射CCl4,每周2次,连续注射8周诱导肝纤维化。分别于第0、2、4、8周分离肝脏Kupffer细胞。采用墨汁吞噬实验考察Kupffer细胞的吞噬能力,采用ELISA检测Kupffer细胞中IL-1β、IL-2、IL-6、IL-10、TNF-α、TGF-β1的含量,采...  (本文共6页) 阅读全文>>

《生命的化学》2019年03期
生命的化学

Kupffer细胞在非酒精性脂肪肝病中的作用

非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)是一种无过量饮酒史、以肝细胞脂肪变性和脂肪贮积为特征的临床病理综合征。Kup...  (本文共8页) 阅读全文>>

《Science China(Life Sciences)》2016年12期
Science China(Life Sciences)

Inflammation-induced CD69~+ Kupffer cell feedback inhibits T cell proliferation via membrane-bound TGF-β1

Kupffer cells,tissue-resident macrophage lineage cell,are enriched in vertebrate liver.The mouse F4/80~+ Kupffer cells have been subclassified into two subpopulations according to their phenotype and function:CD68~+ subpopulation with potent reactive oxygen species(ROS) production and phagocytic capacities,and CD11b~+ subpopulation with a potent capacity to produce T helper 1 cytokines.In addition,CD11b~+ Kupffer cel...  (本文共11页) 阅读全文>>

《Science in China(Series C:Life Sciences)》2009年02期
Science in China(Series C:Life Sciences)

Hyaluronic acid fragments evoke Kupffer cells via TLR4 signaling pathway

Kupffer cells, expressing toll-like receptor 4 (TLR4), play a central role in hepatic ischemia/reperfusion (I/R) injury. Hyaluronic acid (HA) fragments, degradative products of high-molecular-weight HA (HMW-HA), acquire the ability to activate immune cells under inflammatory conditions. Here we inves- tigated whether HA fragments could activate Kupffer cells and analyzed the underlying mechanism. Kupffer cells were i...  (本文共8页) 阅读全文>>