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Regulatory Effect of Shenge Yifei Capsule on TGF-β1/Smad Signaling Pathway in Rats with Chronic Obstructive Pulmonary Disease

[Objectives] This study aimed to study the effects of Shenge Yifei capsule on the TGF-β1/Smad signaling pathway in rats with chronic obstructive pulmonary disease(COPD). [Methods] Ten rats were randomly selected as the control group, and the other 40 rats were selected for modeling by fumigation combined with Klebsiella pneumoniae infection. A total of 38 rats were successfully modeled. They were randomly divided int  (本文共4页) 阅读全文>>

《Chinese Journal of Integrative Medicine》2020年05期
Chinese Journal of Integrative Medicine

Linggui Zhugan Decoction(苓桂术甘汤) Inhibits Ventricular Remodeling after Acute Myocardial Infarction in Rats by Suppressing TGF-β1/Smad Signaling Pathway

Objective: To investigate the inhibitory effect of Linggui Zhugan Decoction(LZD, 苓桂术甘汤) on the ventricular remodeling(VR) after acute myocardial infarction(AMI) and related m RNA and proteins expression in transforming growth factor-beta 1(TGF-β_1)/Smad signaling pathway, and explain its putative mechanism. Methods: A VR model was generated by ligation of coronary artery in rats. Two weeks after surgery, 60 rats were...  (本文共8页) 阅读全文>>

《Chinese Journal of Integrative Medicine》2020年03期
Chinese Journal of Integrative Medicine

Qingxuan Jiangya Decoction(清眩降压汤) Prevents Blood Pressure Elevation and Ameliorates Vascular Structural Remodeling via Modulating TGF-β 1/Smad Pathway in Spontaneously Hypertensive Rats

Objective: To elevate the effects of Qingxuan Jiangya Decoction(清眩降压汤,QXJYD) on hypertension and vascular structural remodeling(VSR) in spontaneously hypertensive rats(SHRs), and investigate the underlying mechanisms. Methods: SHRs(n=8) were given intra-gastric administration with 60 mg/kg of QXJYD or saline, daily for 8 weeks, while rats in SHR-control(n=8) and WKY(n=8) groups were received equal volumes of saline s...  (本文共8页) 阅读全文>>

《Chinese Journal of Natural Medicines》2020年08期
Chinese Journal of Natural Medicines

Early intervention with Di-Dang Decoction prevents macrovascular fibrosis in diabetic rats by regulating the TGF-β1/Smad signalling pathway

Macroangiopathy is a complication of Type II Diabetes Mellitus(T2 DM), which is mainly caused by fibrosis of blood vessels. Using T2 DM rat models, we investigated whether the traditional Chinese medicine, Di-Dang Decoction(DDD), exhibited antifibrotic actions on great vessels. T2 DM rats were randomly divided into non-intervention group, early-, middle-, late-stage DDD intervention groups and control groups, includi...  (本文共8页) 阅读全文>>

《实用口腔医学杂志》2019年01期
实用口腔医学杂志

TGFβ/Smad信号通路在口腔鳞癌热疗中的表达变化

目的:探讨TGFβ/Smad信号通路在口腔鳞状细胞癌(OSCC)热疗之后相关分子的表达变化。方法:利用实时荧光定量RT-PCR和Western blot检测局部加热对OSCC荷瘤裸鼠肿瘤细胞中TGFβ,Smad2,Smad3,Smad4和Smad7的mRNA和蛋白表达的变化。结果:加热组(n=10)中TGFβ、Smad2、S...  (本文共4页) 阅读全文>>

《Journal of Traditional Chinese Medicine》2019年03期
Journal of Traditional Chinese Medicine

Wulong Xiaozheng Wan medicated serum inhibits epithelial-mesenchymal transition in human gastric carcinoma cell line BGC823 by modulation of transforming growth factor-β_1/Smad signaling

OBJECTIVE:To evaluate the effect of Wulong Xiaozheng Wan medicated serum on the epithelial-mesenchymal transition(EMT)of BGC823 cell induced by transforming growth factor-β_1(TGF-β_1)and to explore its mechanism.METHODS:EMT model of BGC823 was stimulated by TGF-β_1.Wulong Xiaozheng Wan medicated serum and LY-364947 were used as intervention.The proliferation and adhesion of BGC823 were detected by 3-(4,5-dimethyl-2-t...  (本文共13页) 阅读全文>>