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MMP-9和TIMP-1在实验性肺气肿大鼠肺组织中的表达及其意义

目的 研究基质金属蛋白酶(MMP-9)及其组织抑制因子(TIMP-1)在弹性蛋白酶所致肺气肿大鼠肺组织中的表达。方法 雄性Wistar大鼠20只,随机分为二组正常对照组和肺气肿模型组,每组10只。模型组大鼠气管内  (本文共3页) 阅读全文>>

《福建医药杂志》2004年02期
福建医药杂志

兔主动脉球囊损伤后TIMP-1的mRNA动态表达

目的 探讨基质金属蛋白酶组织抑制因子-1(TIMP-1)mRNA在球囊损伤后的改变及可能作用。方法 在兔腹主动脉球囊损伤的模型上,应用RT-PCR的方法,观察T...  (本文共3页) 阅读全文>>

《Chinese Medical Sciences Journal》2004年02期
Chinese Medical Sciences Journal

SIGNIFICANCE OF MMP-2 AND TIMP-2 mRNA EXPRESSIONS ON GLOMERULAR CELLS IN THE DEVELOPMENT OF GLOMERULOSCLEROSIS

Objective To study the expressions of MMP-2 and TIMP-2 mRNA on cultured rat mesangial cells (MsC) and in human diseased glomeruli, and to explore their significance in the development of glomerulosclerosis. Methods The expressions of MMP-2, TIMP-2, and Col ⅣmRNA on cultured rat MsC stimulated by IL-1 or/and TGF-β1were investigated through Northern blot analysis. The levels of MMP-2 and TIMP-2 mRNA expressions and imm...  (本文共5页) 阅读全文>>

《临床心血管病杂志》2004年09期
临床心血管病杂志

阿托伐他汀对急性冠状动脉综合征患者血清MMP-9及TIMP-1水平的影响

目的 :测定急性冠状动脉综合征 (ACS)患者经阿托伐他汀治疗前后血清明胶酶B(MMP 9)、基质金属蛋白酶组织抑制因子 1 (TIMP 1 )水平 ,探讨两者水平与粥样斑块破裂的关系及他汀类调脂药物稳定斑块的可能机制。方法 :选择稳定型心绞痛 (SAP)患者 3 0例 ,ACS患者 5 4例 ,并选择 3 0例健康人作...  (本文共3页) 阅读全文>>

《World Journal of Gastroenterology》2004年01期
World Journal of Gastroenterology

Expression of TIMP-1 and TIMP-2 in rats with hepatic fibrosis

AIM:To investigate the location and expression of TIMP-1and TIMP-2 in the liver of normal and experimental hepaticfibrosis in rats.METHODS:The rat models of experimental immunityhepatic fibrosis (n=20) were prepared by the means ofimmunologic attacking with human serum albumin (HSA),and normal rats (n=10) served as control group.Bothimmunohistochemistry and in situ hybridization methodswere respectively used to detec...  (本文共5页) 阅读全文>>

《Cellular & Molecular Immunology》2004年04期
Cellular & Molecular Immunology

Expression of TIMP-3 Gene by Construction of a Eukaryotic Cell Expression Vector and Its Role in Reduction of Metastasis in a Human Breast Cancer Cell Line

The present study is aimed at studying the gene for TIMP-3,a mammalian tissue inhibitor,by constructing arecombinant eukaryotic cell vector for gene therapy in human breast cancer.We obtained the TIMP-3 genefrom the human placent by RT-PCR.TIMP-3 gene was subcloned into pcDNA3.1 vetor from pMD18T vectorby means of gene cloning to construct pcDNA3.1 recombinant vector.Human breast cancer cell lineMDA-MB-453 was transf...  (本文共3页) 阅读全文>>