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新生儿缺氧缺血性脑病血清caspase-1和IL-1β测定及意义

目的探讨新生儿缺氧缺血性脑病(HIE)血清半胱氨酸酶-1(caspase-1)和白细胞介素-1β(IL-1β)的变化以及两者与脑组织损伤程度之间的关系。方法采用酶联免疫吸附法(ELISA)检测70例HIE患儿(分轻、中、重三组)及22例正常对照组新生儿第三天血清caspase-1和IL-1β的水平。结果(1)与对  (本文共2页) 阅读全文>>

《临床军医杂志》2007年01期
临床军医杂志

Caspase-3在翼状胬肉中的表达及临床意义

目的探讨Caspase-3在翼状胬肉中的表达及发病过程中的作用。方法采用免疫组化Elivision法检测20例翼状胬肉、10例正常结膜中Caspase-3的表达。结果20例翼状胬肉中...  (本文共2页) 阅读全文>>

《World Journal of Gastroenterology》2007年04期
World Journal of Gastroenterology

Therapeutic effects of Caspase-1 inhibitors on acute lung injury in experimental severe acute pancreatitis

AIM: To assess the therapeutic effect of Caspase-1 inhibitors (ICE-I) on acute lung injury (ALI) in experimental severe acute pancreatitis (SAP). METHODS: Forty-two SD rats were randomly divided into 3 groups: healthy controls (HC, n = 6); SAP-S group (n = 18); SAP-ICE-I group (n = 18). SAP was induced by retrograde infusion of 5% sodium taurocholate into the bile-pancreatic duct. HC rats underwent the same surgical ...  (本文共5页) 阅读全文>>

《医学综述》2007年07期
医学综述

Caspase与病理性瘢痕

Caspase是一类半胱氨酸天冬氨酸特异性蛋白酶家族,该家族是执行细胞凋亡的主要酶类,近年来...  (本文共3页) 阅读全文>>

《Cell Research》2007年06期
Cell Research

Parthenolide protects human lens epithelial cells from oxidative stress-induced apoptosis via inhibition of activation of caspase-3 and caspase-9

The apoptosis of lens epithelial cells has been proposed as the common basis of cataract formation, with oxidative stressas the major cause. This study was performed to investigate the protective effect of the herbal constituent parthenolideagainst oxidative stress-induced apoptosis of human lens epithelial (HLE) cells and the possible molecular mechanismsinvolved. HLE cells (SRA01-04) were incubated with 50μM H_2O_2...  (本文共7页) 阅读全文>>

《中国现代医学杂志》2007年22期
中国现代医学杂志

Caspase-3蛋白在喉癌中的表达及其临床意义

目的研究喉癌中Caspase-3的表达与相关病理生物学行为及其对临床预后的影响。方法应用免疫组化法检测68例原发喉癌组织中Caspase-3基因蛋白的表达情况。结果68例喉癌中Caspase-3呈阳性...  (本文共3页) 阅读全文>>